MyBioSource.com's Rabbit Anti-SIRT5/Sirtuin 5 Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-SIRT5/Sirtuin 5 Antibody was generated using sirt5, and sirtuin 5 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Western Blot.
Description
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed: 21908771, PubMed: 22076378, PubMed: 24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed: 22076378, PubMed: 24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed: 24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX